Biotransformation and Metabolite Elucidation of Xenobiotics: - download pdf or read online

By Ala F. Nassar

ISBN-10: 0470504781

ISBN-13: 9780470504789

The target of this e-book is to enhance the readers' wisdom of metabolite elucidation in drug metabolism by means of exposing them to intensive assurance of the biotransformation of xenobiotics, suggestions for deciding upon and characterizing metabolites, FDA directions, and case reviews on the way to increase the decision-making approach in structural amendment of drug applicants to minimize toxicity.

The ebook includes eight chapters; it first offers an advent on biotransformation of xenobiotics, after which offers glossy ways and methods for facing metabolite characterization, utilizing instruments comparable to LC-MS, H-D trade, solid isotopes LC-MS-NMR, and radiolabeled compounds. additionally, suggestions for facing reactive intermediates in drug discovery and improvement are awarded in addition to case reports on bettering the decision-making technique within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of safeguard checking out of drug metabolites and why, how, and while to check their safety.

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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar

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