By Ala F. Nassar
The ebook includes eight chapters; it first offers an advent on biotransformation of xenobiotics, after which offers glossy ways and methods for facing metabolite characterization, utilizing instruments comparable to LC-MS, H-D trade, solid isotopes LC-MS-NMR, and radiolabeled compounds. additionally, suggestions for facing reactive intermediates in drug discovery and improvement are awarded in addition to case reports on bettering the decision-making technique within the structural amendment of drug applicants. The final bankruptcy discusses the regulatory views of safeguard checking out of drug metabolites and why, how, and while to check their safety.
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Biotransformation and Metabolite Elucidation of Xenobiotics: Characterization and Identification by Ala F. Nassar